Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility

Christina J. Newcomb, Shantanu Sur, Sungsoo S. Lee, Jeong Min Yu, Yan Zhou, Malcolm L. Snead, Samuel I Stupp

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The nanostructures of self-assembling biomaterials have been previously designed to tune the release of growth factors in order to optimize biological repair and regeneration. We report here on the discovery that weakly cohesive peptide nanostructures in terms of intermolecular hydrogen bonding, when combined with low concentrations of osteogenic growth factor, enhance both BMP-2 and Wnt mediated signaling in myoblasts and bone marrow stromal cells, respectively. Conversely, analogous nanostructures with enhanced levels of internal hydrogen bonding and cohesion lead to an overall reduction in BMP-2 signaling. We propose that the mechanism for enhanced growth factor signaling by the nanostructures is related to their ability to increase diffusion within membrane lipid rafts. The phenomenon reported here could lead to new nanomedicine strategies to mediate growth factor signaling for translational targets.

Original languageEnglish
Pages (from-to)3042-3050
Number of pages9
JournalNano Letters
Volume16
Issue number5
DOIs
Publication statusPublished - May 11 2016

Fingerprint

rafts
Nanofibers
Lipids
lipids
Nanostructures
Intercellular Signaling Peptides and Proteins
Hydrogen bonds
Medical nanotechnology
bone marrow
cohesion
Biocompatible Materials
hydrogen
Membrane Lipids
assembling
regeneration
Biomaterials
Peptides
peptides
low concentrations
Bone

Keywords

  • BMP-2
  • growth factor signaling
  • lipid raft
  • LRAP
  • Self-assembly

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility. / Newcomb, Christina J.; Sur, Shantanu; Lee, Sungsoo S.; Yu, Jeong Min; Zhou, Yan; Snead, Malcolm L.; Stupp, Samuel I.

In: Nano Letters, Vol. 16, No. 5, 11.05.2016, p. 3042-3050.

Research output: Contribution to journalArticle

Newcomb, Christina J. ; Sur, Shantanu ; Lee, Sungsoo S. ; Yu, Jeong Min ; Zhou, Yan ; Snead, Malcolm L. ; Stupp, Samuel I. / Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility. In: Nano Letters. 2016 ; Vol. 16, No. 5. pp. 3042-3050.
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