Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents

Bin Wang, Jing Li, Wen Long Huang, Hui Bin Zhang, Hai Qian, Yong Tang Zheng

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14 Citations (Scopus)


A series of Andro derivatives were described and evaluated for their anti-HIV activity in vitro. Compound 10 and 16b, of which TI were >10, had some anti-HIV-1 activity in vitro. Therein, compound 10 which was the best potent compound, could serve as a new lead for further development of anti-AIDS agents.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalChinese Chemical Letters
Issue number7
Publication statusPublished - Jul 1 2011



  • Andrographolide
  • Anti-HIV
  • Derivatives
  • Natural products
  • Synthesis

ASJC Scopus subject areas

  • Chemistry(all)

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