Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents

Bin Wang, Jing Li, Wen Long Huang, Hui Bin Zhang, Hai Qian, Yong Tang Zheng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A series of Andro derivatives were described and evaluated for their anti-HIV activity in vitro. Compound 10 and 16b, of which TI were >10, had some anti-HIV-1 activity in vitro. Therein, compound 10 which was the best potent compound, could serve as a new lead for further development of anti-AIDS agents.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalChinese Chemical Letters
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 2011

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Anti-HIV Agents
Derivatives
Lead
andrographolide

Keywords

  • Andrographolide
  • Anti-HIV
  • Derivatives
  • Natural products
  • Synthesis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents. / Wang, Bin; Li, Jing; Huang, Wen Long; Zhang, Hui Bin; Qian, Hai; Zheng, Yong Tang.

In: Chinese Chemical Letters, Vol. 22, No. 7, 07.2011, p. 781-784.

Research output: Contribution to journalArticle

Wang, Bin ; Li, Jing ; Huang, Wen Long ; Zhang, Hui Bin ; Qian, Hai ; Zheng, Yong Tang. / Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents. In: Chinese Chemical Letters. 2011 ; Vol. 22, No. 7. pp. 781-784.
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