Synthesis and electrochemical characterization of a transition-metal- modified ligand - Receptor pair

Amanda L. Eckermann, Kylie D. Barker, Matthew R. Hartings, Mark A Ratner, Thomas J. Meade

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The energetics of weak interactions (van der Waals forces, hydrogen bonding) are difficult to quantify in biological ligand-receptor pairs. Insight into the biochemical role these forces play is critical to an understanding of signal transduction events and the drug discovery process. Ruthenium pentaammine and iron tetracyano complexes modified with either biotin or desthiobiotin have been synthesized and characterized. These modified biological ligands bind to the protein avidin in a manner similar to that of native biotin. Experiments using redox mediators show that the avidin-bound complexes are electrochemically accessible.

Original languageEnglish
Pages (from-to)11880-11881
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number34
DOIs
Publication statusPublished - Aug 31 2005

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Avidin
Biotin
Transition metals
Metals
Ligands
Signal transduction
Van der Waals forces
Ruthenium
Drug Discovery
Hydrogen Bonding
Oxidation-Reduction
Signal Transduction
Hydrogen bonds
Iron
Proteins
Experiments
desthiobiotin

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis and electrochemical characterization of a transition-metal- modified ligand - Receptor pair. / Eckermann, Amanda L.; Barker, Kylie D.; Hartings, Matthew R.; Ratner, Mark A; Meade, Thomas J.

In: Journal of the American Chemical Society, Vol. 127, No. 34, 31.08.2005, p. 11880-11881.

Research output: Contribution to journalArticle

Eckermann, Amanda L. ; Barker, Kylie D. ; Hartings, Matthew R. ; Ratner, Mark A ; Meade, Thomas J. / Synthesis and electrochemical characterization of a transition-metal- modified ligand - Receptor pair. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 34. pp. 11880-11881.
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