Synthesis of a poly(L-lysine)-calcium phosphate hybrid on titanium surfaces for enhanced bioactivity

Erik D. Spoerke, Samuel I Stupp

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Titanium has been a successful implant material owing to its excellent strength to weight ratio, toughness, and bioinert oxide surface. Significant progress has been made on the improvement of titanium's bioactivity by coating its oxide surface with calcium phosphates and bioactive molecules. Here, we report on the coating of titanium with a poly(l-lysine)-calcium phosphate hybrid material with a nanoscale texture. This hybrid coating was grown by first nucleating seed crystals of calcium phosphate, directly on the Ti surface and then exposing this surface to solutions containing Ca2+, PO 43-, and poly(l-lysine). The resultant hybrid coating was characterized by electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, and elemental analysis. This material contained 14% by weight poly(l-lysine), and this organic component decreased greatly the dimensions of the surface features, thus enhancing surface area relative to the inorganic control. The highly textured hybrid material was more susceptible than the control to acidic and enzymatic degradation. The amino acid cysteine was covalently linked to the hybrid material, demonstrating the potential of this coating for further functionalization. These hybrid coatings may prove useful in enhancing the bioactivity of titanium.

Original languageEnglish
Pages (from-to)5120-5129
Number of pages10
JournalBiomaterials
Volume26
Issue number25
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Calcium phosphate
Bioactivity
Titanium
Lysine
Coatings
Hybrid materials
Oxides
Calcium Phosphates
Weights and Measures
Photoelectron Spectroscopy
Fourier Transform Infrared Spectroscopy
X-Ray Diffraction
Electron microscopy
Toughness
Fourier transform infrared spectroscopy
Cysteine
Thermogravimetric analysis
calcium phosphate
Amino acids
Electron Microscopy

Keywords

  • Calcium phosphate
  • Covalent attachment
  • Degradation
  • Hybrid
  • Poly(L-lysine)
  • Titanium

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Synthesis of a poly(L-lysine)-calcium phosphate hybrid on titanium surfaces for enhanced bioactivity. / Spoerke, Erik D.; Stupp, Samuel I.

In: Biomaterials, Vol. 26, No. 25, 09.2005, p. 5120-5129.

Research output: Contribution to journalArticle

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