Synthesis of aromatic aldehydes by oxidative hydroxymethylation

Oiena Branytska, Ronny Neumann

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A new high yield method for the synthesis of aromatic aldehydes has been developed. The procedure is based on an acid catalyzed hydroxymethylation of an arene substrate by paraformaldehyde with concurrent selective oxidation of the intermediate aromatic carbinol by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) to the aldehyde product.

Original languageEnglish
Pages (from-to)1575-1576
Number of pages2
JournalSynlett
Issue number9
Publication statusPublished - Jul 22 2004

Fingerprint

Aldehydes
Methanol
Oxidation
Acids
Substrates
dichlorodicyanobenzoquinone
paraform

Keywords

  • Aldehydes
  • Arenes
  • Electrophilic aromatic substitutions
  • Oxidations
  • Quinones

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of aromatic aldehydes by oxidative hydroxymethylation. / Branytska, Oiena; Neumann, Ronny.

In: Synlett, No. 9, 22.07.2004, p. 1575-1576.

Research output: Contribution to journalArticle

@article{86ed51649f8b4c2fabf8d2e8396f5168,
title = "Synthesis of aromatic aldehydes by oxidative hydroxymethylation",
abstract = "A new high yield method for the synthesis of aromatic aldehydes has been developed. The procedure is based on an acid catalyzed hydroxymethylation of an arene substrate by paraformaldehyde with concurrent selective oxidation of the intermediate aromatic carbinol by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) to the aldehyde product.",
keywords = "Aldehydes, Arenes, Electrophilic aromatic substitutions, Oxidations, Quinones",
author = "Oiena Branytska and Ronny Neumann",
year = "2004",
month = "7",
day = "22",
language = "English",
pages = "1575--1576",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "9",

}

TY - JOUR

T1 - Synthesis of aromatic aldehydes by oxidative hydroxymethylation

AU - Branytska, Oiena

AU - Neumann, Ronny

PY - 2004/7/22

Y1 - 2004/7/22

N2 - A new high yield method for the synthesis of aromatic aldehydes has been developed. The procedure is based on an acid catalyzed hydroxymethylation of an arene substrate by paraformaldehyde with concurrent selective oxidation of the intermediate aromatic carbinol by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) to the aldehyde product.

AB - A new high yield method for the synthesis of aromatic aldehydes has been developed. The procedure is based on an acid catalyzed hydroxymethylation of an arene substrate by paraformaldehyde with concurrent selective oxidation of the intermediate aromatic carbinol by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) to the aldehyde product.

KW - Aldehydes

KW - Arenes

KW - Electrophilic aromatic substitutions

KW - Oxidations

KW - Quinones

UR - http://www.scopus.com/inward/record.url?scp=3943069018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3943069018&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:3943069018

SP - 1575

EP - 1576

JO - Synlett

JF - Synlett

SN - 0936-5214

IS - 9

ER -