Synthesis of peptides and pyrazines from β-amino alcohols through extrusion of h 2 catalyzed by ruthenium pincer complexes: Ligand-controlled selectivity

Boopathy Gnanaprakasam, Ekambaram Balaraman, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

111 Citations (Scopus)


Your choice: The choice of the Ru-pincer-complex catalyst determines if peptides or pyrazines are formed from β-amino alcohols. Use of PNN complex 1 leads to linear poly(alanine) or to cyclic dipeptides, depending on the R group (see scheme). With the PNP complex 2, pyrazines are formed. These reactions are homogeneously catalyzed under neutral conditions and are environmentally benign.

Original languageEnglish
Pages (from-to)12240-12244
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number51
Publication statusPublished - Dec 16 2011



  • dehydrogenation
  • homogeneous catalysis
  • peptides
  • pyrazines
  • ruthenium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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