Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes

Prosenjit Daw, Amit Kumar, Noel Angel Espinosa-Jalapa, Yael Diskin-Posner, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.

Original languageEnglish
Pages (from-to)7734-7741
Number of pages8
JournalACS Catalysis
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 7 2018

Keywords

  • dehydrogenative coupling
  • manganese
  • pincer
  • pyrazine
  • quinoxaline

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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