Abstract
Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.
| Original language | English |
|---|---|
| Pages (from-to) | 7734-7741 |
| Number of pages | 8 |
| Journal | ACS Catalysis |
| Volume | 8 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 7 2018 |
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Keywords
- dehydrogenative coupling
- manganese
- pincer
- pyrazine
- quinoxaline
ASJC Scopus subject areas
- Catalysis
Cite this
Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes. / Daw, Prosenjit; Kumar, Amit; Espinosa-Jalapa, Noel Angel; Diskin-Posner, Yael; Ben-David, Yehoshoa; Milstein, David.
In: ACS Catalysis, Vol. 8, No. 9, 07.09.2018, p. 7734-7741.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes
AU - Daw, Prosenjit
AU - Kumar, Amit
AU - Espinosa-Jalapa, Noel Angel
AU - Diskin-Posner, Yael
AU - Ben-David, Yehoshoa
AU - Milstein, David
PY - 2018/9/7
Y1 - 2018/9/7
N2 - Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.
AB - Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.
KW - dehydrogenative coupling
KW - manganese
KW - pincer
KW - pyrazine
KW - quinoxaline
UR - http://www.scopus.com/inward/record.url?scp=85050738559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050738559&partnerID=8YFLogxK
U2 - 10.1021/acscatal.8b02208
DO - 10.1021/acscatal.8b02208
M3 - Article
AN - SCOPUS:85050738559
VL - 8
SP - 7734
EP - 7741
JO - ACS Catalysis
JF - ACS Catalysis
SN - 2155-5435
IS - 9
ER -