Abstract
Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.
| Original language | English |
|---|---|
| Pages (from-to) | 7734-7741 |
| Number of pages | 8 |
| Journal | ACS Catalysis |
| Volume | 8 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 7 2018 |
Keywords
- dehydrogenative coupling
- manganese
- pincer
- pyrazine
- quinoxaline
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Daw, P., Kumar, A., Espinosa-Jalapa, N. A., Diskin-Posner, Y., Ben-David, Y., & Milstein, D. (2018). Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes. ACS Catalysis, 8(9), 7734-7741. https://doi.org/10.1021/acscatal.8b02208