Abstract
We have prepared and characterized a series of novel polydentate N,O-donor ligands derived from our well-studied ligand 2-(2-pyridinyl)-2-propanol (pyalkH), having the general formula Me{C(OH)(2-py)CH2}nH, where n = 2 or 3. Like pyalkH, these analogues bind via N and O with deprotonation at the latter, thus extending the strongly donor pyridine-alkoxide chelation power of pyalkH to polydentate forms. The greater denticity allows for more effective binding and polynuclear cluster formation with first-row transition metals. Several stable alkoxo-bridged polynuclear clusters of these ligands with Mn, Cu, Co and Ni have been prepared; all reported ligands and complexes have been characterized, including by X-ray crystallography. We report a one-step synthesis of these ligands, alongside pyalkH, on a multi-gram scale from inexpensive starting materials. We have also developed a new scalable procedure for the isolation of pyalkH that avoids the need for chromatography, making large-scale production of this ligand commercially viable.
| Original language | English |
|---|---|
| Pages (from-to) | 6709-6719 |
| Number of pages | 11 |
| Journal | New Journal of Chemistry |
| Volume | 41 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
Fingerprint
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Materials Chemistry
Cite this
Synthesis of pyridine-alkoxide ligands for formation of polynuclear complexes. / Shopov, Dimitar Y.; Sharninghausen, Liam S.; Sinha, Shashi Bhushan; Borowski, Julia E.; Mercado, Brandon Q.; Brudvig, Gary W; Crabtree, Robert H.
In: New Journal of Chemistry, Vol. 41, No. 14, 01.01.2017, p. 6709-6719.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of pyridine-alkoxide ligands for formation of polynuclear complexes
AU - Shopov, Dimitar Y.
AU - Sharninghausen, Liam S.
AU - Sinha, Shashi Bhushan
AU - Borowski, Julia E.
AU - Mercado, Brandon Q.
AU - Brudvig, Gary W
AU - Crabtree, Robert H.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - We have prepared and characterized a series of novel polydentate N,O-donor ligands derived from our well-studied ligand 2-(2-pyridinyl)-2-propanol (pyalkH), having the general formula Me{C(OH)(2-py)CH2}nH, where n = 2 or 3. Like pyalkH, these analogues bind via N and O with deprotonation at the latter, thus extending the strongly donor pyridine-alkoxide chelation power of pyalkH to polydentate forms. The greater denticity allows for more effective binding and polynuclear cluster formation with first-row transition metals. Several stable alkoxo-bridged polynuclear clusters of these ligands with Mn, Cu, Co and Ni have been prepared; all reported ligands and complexes have been characterized, including by X-ray crystallography. We report a one-step synthesis of these ligands, alongside pyalkH, on a multi-gram scale from inexpensive starting materials. We have also developed a new scalable procedure for the isolation of pyalkH that avoids the need for chromatography, making large-scale production of this ligand commercially viable.
AB - We have prepared and characterized a series of novel polydentate N,O-donor ligands derived from our well-studied ligand 2-(2-pyridinyl)-2-propanol (pyalkH), having the general formula Me{C(OH)(2-py)CH2}nH, where n = 2 or 3. Like pyalkH, these analogues bind via N and O with deprotonation at the latter, thus extending the strongly donor pyridine-alkoxide chelation power of pyalkH to polydentate forms. The greater denticity allows for more effective binding and polynuclear cluster formation with first-row transition metals. Several stable alkoxo-bridged polynuclear clusters of these ligands with Mn, Cu, Co and Ni have been prepared; all reported ligands and complexes have been characterized, including by X-ray crystallography. We report a one-step synthesis of these ligands, alongside pyalkH, on a multi-gram scale from inexpensive starting materials. We have also developed a new scalable procedure for the isolation of pyalkH that avoids the need for chromatography, making large-scale production of this ligand commercially viable.
UR - http://www.scopus.com/inward/record.url?scp=85022329258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85022329258&partnerID=8YFLogxK
U2 - 10.1039/c7nj01845b
DO - 10.1039/c7nj01845b
M3 - Article
VL - 41
SP - 6709
EP - 6719
JO - New Journal of Chemistry
JF - New Journal of Chemistry
SN - 1144-0546
IS - 14
ER -