Template-directed nucleation and growth of inorganic nanoparticles on DNA scaffolds

Linda A. Stearns, Rahul Chhabra, Jaswinder Sharma, Yan Liu, William T. Petuskey, Hao Yan, John C. Chaput

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


DNA origami: A DNA nanotube containing gold-binding peptides can nucleate nanoparticles of a discrete size from soluble chemical precursors. The peptide-DNA nanostructure was used to direct the assembly of an inorganic nanostructure, with gold nanoparticles distributed along the surface of the DNA nanotube (see picture). The resulting nanostructure is an important step forward in the synthesis of programmable inorganic materials by self-assembly.

Original languageEnglish
Pages (from-to)8494-8496
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number45
Publication statusPublished - Oct 26 2009


  • DNA
  • Inorganic nanostructures
  • Inorganic-binding peptides
  • Nanoparticles
  • Nanotechnology

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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