Terahertz coherent anti-stokes raman scattering microscopy

Liqing Ren, Ilan Hurwitz, Dekel Raanan, Patric Oulevey, Dan Oron, Yaron Silberberg

Research output: Contribution to journalLetter

Abstract

Vibrational spectroscopic imaging is useful and important in biological and medical studies. Yet, vibrational imaging in the terahertz region (<300 cm−1) under biologically relevant conditions is currently unavailable, as none of the available methods possesses a sufficient sensitivity and high spatial resolution at the same time. Here, we develop a terahertz coherent anti-Stokes Raman scattering (THz-CARS) microscope with a high sensitivity and high spatial resolution that shows chemically selective imaging of biological tissues by using low-frequency collective modes of the corresponding constituents, filling the existing energy scale gap for vibrational imaging in the THz region. The observation of collective modes of biomacromolecules, such as collagen and non-collagenous proteins, may have significant implications for elucidating their corresponding biological functions, and the methodology presented may find wider applications in bio-medical research.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalOptica
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 20 2019

Fingerprint

Raman scattering
Microscopic examination
spatial resolution
Raman spectra
microscopy
Imaging techniques
sensitivity
high resolution
collagens
microscopes
methodology
low frequencies
proteins
Collagen
Microscopes
Tissue
Proteins
energy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Ren, L., Hurwitz, I., Raanan, D., Oulevey, P., Oron, D., & Silberberg, Y. (2019). Terahertz coherent anti-stokes raman scattering microscopy. Optica, 6(1), 52-55. https://doi.org/10.1364/OPTICA.6.000052

Terahertz coherent anti-stokes raman scattering microscopy. / Ren, Liqing; Hurwitz, Ilan; Raanan, Dekel; Oulevey, Patric; Oron, Dan; Silberberg, Yaron.

In: Optica, Vol. 6, No. 1, 20.01.2019, p. 52-55.

Research output: Contribution to journalLetter

Ren, L, Hurwitz, I, Raanan, D, Oulevey, P, Oron, D & Silberberg, Y 2019, 'Terahertz coherent anti-stokes raman scattering microscopy', Optica, vol. 6, no. 1, pp. 52-55. https://doi.org/10.1364/OPTICA.6.000052
Ren L, Hurwitz I, Raanan D, Oulevey P, Oron D, Silberberg Y. Terahertz coherent anti-stokes raman scattering microscopy. Optica. 2019 Jan 20;6(1):52-55. https://doi.org/10.1364/OPTICA.6.000052
Ren, Liqing ; Hurwitz, Ilan ; Raanan, Dekel ; Oulevey, Patric ; Oron, Dan ; Silberberg, Yaron. / Terahertz coherent anti-stokes raman scattering microscopy. In: Optica. 2019 ; Vol. 6, No. 1. pp. 52-55.
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