The chemical and physical characteristics of single-walled carbon nanotube film impact on osteoblastic cell response

Wojtek Tutak, Manish Chhowalla, Federico Sesti

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Carbon-nanotube-based substrates have been shown to support the growth of different cell types and, as such, have raised considerable interest in view of their possible use in biomedical applications. Nanotube matrices are embedded in polymers which cause inherent changes in nanotube chemical and physical film properties. Thus, it is critical to understand how the physical properties of the film affect the biology of the host tissue. Here, we investigated how the physical and chemical properties of single-walled carbon nanotubes (SWNT) films impact the response of MC3T3-E1 bone osteoblasts. We found that two fundamental steps in cell growth - initial attachment to the substrate and proliferation - are strongly dependent on, respectively, the energy and roughness of the surface. Thus, fine-tuning the properties of the film may represent a valid strategy to optimize the response of the biological host.

Original languageEnglish
Article number315102
JournalNanotechnology
Volume21
Issue number31
DOIs
Publication statusPublished - Jul 12 2010

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ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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