The structure of bryostatin 2 from the marine Bryozoan Bugula neritina

George R. Pettit, Cherry L. Herald, Yoshiaki Kamano, John Devens Gust, Reiko Aoyagi

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The marine Bryozoan Bugula neritina L. has been found to contain a new series (17) of related macrolides remarkably active against the murine P-388 lymphocytic leukemia. Based primarily upon high resolution (400 MHz) 1H-nmr studies, the second member of the series, bryostatin 2, has been shown to be the 20-membered ring lactone 1b.

Original languageEnglish
Pages (from-to)528-531
Number of pages4
JournalJournal of Natural Products
Volume46
Issue number4
Publication statusPublished - 1983

Fingerprint

bryostatins
Lymphoid Leukemia
macrolides
lymphocytic leukemia
Macrolides
Lactones
lactones
mice
bryostatin 2

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Pettit, G. R., Herald, C. L., Kamano, Y., Gust, J. D., & Aoyagi, R. (1983). The structure of bryostatin 2 from the marine Bryozoan Bugula neritina. Journal of Natural Products, 46(4), 528-531.

The structure of bryostatin 2 from the marine Bryozoan Bugula neritina. / Pettit, George R.; Herald, Cherry L.; Kamano, Yoshiaki; Gust, John Devens; Aoyagi, Reiko.

In: Journal of Natural Products, Vol. 46, No. 4, 1983, p. 528-531.

Research output: Contribution to journalArticle

Pettit, GR, Herald, CL, Kamano, Y, Gust, JD & Aoyagi, R 1983, 'The structure of bryostatin 2 from the marine Bryozoan Bugula neritina', Journal of Natural Products, vol. 46, no. 4, pp. 528-531.
Pettit, George R. ; Herald, Cherry L. ; Kamano, Yoshiaki ; Gust, John Devens ; Aoyagi, Reiko. / The structure of bryostatin 2 from the marine Bryozoan Bugula neritina. In: Journal of Natural Products. 1983 ; Vol. 46, No. 4. pp. 528-531.
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