Thermodynamic factors impacting the peptide-driven self-assembly of perylene diimide nanofibers

Galen L. Eakins, Joseph K. Gallaher, Robert A. Keyzers, Alexander Falber, James E.A. Webb, Alistair Laos, Yaron Tidhar, Haim Weissman, Boris Rybtchinski, Pall Thordarson, Justin M. Hodgkiss

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29 Citations (Scopus)

Abstract

Synthetic peptides offer enormous potential to encode the assembly of molecular electronic components, provided that the complex range of interactions is distilled into simple design rules. Here, we report a spectroscopic investigation of aggregation in an extensive series of peptide-perylene diiimide conjugates designed to interrogate the effect of structural variations. By fitting different contributions to temperature dependent optical absorption spectra, we quantify both the thermodynamics and the nature of aggregation for peptides by incrementally varying hydrophobicity, charge density, length, as well as asymmetric substitution with a hexyl chain, and stereocenter inversion. We find that coarse effects like hydrophobicity and hexyl substitution have the greatest impact on aggregation thermodynamics, which are separated into enthalpic and entropic contributions. Moreover, significant peptide packing effects are resolved via stereocenter inversion studies, particularly when examining the nature of aggregates formed and the coupling between π electronic orbitals. Our results develop a quantitative framework for establishing structure-function relationships that will underpin the design of self-assembling peptide electronic materials.

Original languageEnglish
Pages (from-to)8642-8651
Number of pages10
JournalJournal of Physical Chemistry B
Volume118
Issue number29
DOIs
Publication statusPublished - Jul 24 2014

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Eakins, G. L., Gallaher, J. K., Keyzers, R. A., Falber, A., Webb, J. E. A., Laos, A., Tidhar, Y., Weissman, H., Rybtchinski, B., Thordarson, P., & Hodgkiss, J. M. (2014). Thermodynamic factors impacting the peptide-driven self-assembly of perylene diimide nanofibers. Journal of Physical Chemistry B, 118(29), 8642-8651. https://doi.org/10.1021/jp504564s