Tip-enhanced raman imaging: An emergent tool for probing biology at the nanoscale

Eric A. Pozzi, Matthew D. Sonntag, Nan Jiang, Jordan M. Klingsporn, Mark C Hersam, Richard P. Van Duyne

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.

Original languageEnglish
Pages (from-to)885-888
Number of pages4
JournalACS Nano
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 26 2013

Fingerprint

biology
Diffraction
Imaging techniques
diffraction
Electromagnetic fields
Raman spectroscopy
emerging
electromagnetic fields
spatial resolution
high resolution
spectroscopy
Optical spectroscopy

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Pozzi, E. A., Sonntag, M. D., Jiang, N., Klingsporn, J. M., Hersam, M. C., & Van Duyne, R. P. (2013). Tip-enhanced raman imaging: An emergent tool for probing biology at the nanoscale. ACS Nano, 7(2), 885-888. https://doi.org/10.1021/nn400560t

Tip-enhanced raman imaging : An emergent tool for probing biology at the nanoscale. / Pozzi, Eric A.; Sonntag, Matthew D.; Jiang, Nan; Klingsporn, Jordan M.; Hersam, Mark C; Van Duyne, Richard P.

In: ACS Nano, Vol. 7, No. 2, 26.02.2013, p. 885-888.

Research output: Contribution to journalArticle

Pozzi, EA, Sonntag, MD, Jiang, N, Klingsporn, JM, Hersam, MC & Van Duyne, RP 2013, 'Tip-enhanced raman imaging: An emergent tool for probing biology at the nanoscale', ACS Nano, vol. 7, no. 2, pp. 885-888. https://doi.org/10.1021/nn400560t
Pozzi EA, Sonntag MD, Jiang N, Klingsporn JM, Hersam MC, Van Duyne RP. Tip-enhanced raman imaging: An emergent tool for probing biology at the nanoscale. ACS Nano. 2013 Feb 26;7(2):885-888. https://doi.org/10.1021/nn400560t
Pozzi, Eric A. ; Sonntag, Matthew D. ; Jiang, Nan ; Klingsporn, Jordan M. ; Hersam, Mark C ; Van Duyne, Richard P. / Tip-enhanced raman imaging : An emergent tool for probing biology at the nanoscale. In: ACS Nano. 2013 ; Vol. 7, No. 2. pp. 885-888.
@article{97450c441d244ddb8310bf8ed245b0ee,
title = "Tip-enhanced raman imaging: An emergent tool for probing biology at the nanoscale",
abstract = "Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.",
author = "Pozzi, {Eric A.} and Sonntag, {Matthew D.} and Nan Jiang and Klingsporn, {Jordan M.} and Hersam, {Mark C} and {Van Duyne}, {Richard P.}",
year = "2013",
month = "2",
day = "26",
doi = "10.1021/nn400560t",
language = "English",
volume = "7",
pages = "885--888",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "2",

}

TY - JOUR

T1 - Tip-enhanced raman imaging

T2 - An emergent tool for probing biology at the nanoscale

AU - Pozzi, Eric A.

AU - Sonntag, Matthew D.

AU - Jiang, Nan

AU - Klingsporn, Jordan M.

AU - Hersam, Mark C

AU - Van Duyne, Richard P.

PY - 2013/2/26

Y1 - 2013/2/26

N2 - Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.

AB - Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.

UR - http://www.scopus.com/inward/record.url?scp=84874430984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874430984&partnerID=8YFLogxK

U2 - 10.1021/nn400560t

DO - 10.1021/nn400560t

M3 - Article

C2 - 23441673

AN - SCOPUS:84874430984

VL - 7

SP - 885

EP - 888

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 2

ER -