Tip-enhanced raman imaging: An emergent tool for probing biology at the nanoscale

Eric A. Pozzi; Matthew D. Sonntag; Nan Jiang; Jordan M. Klingsporn; Mark C. Hersam; Richard P. Van Duyne

doi:10.1021/nn400560t

Tip-enhanced raman imaging: An emergent tool for probing biology at the nanoscale

Eric A. Pozzi, Matthew D. Sonntag, Nan Jiang, Jordan M. Klingsporn, Mark C. Hersam, Richard P. Van Duyne

Northwestern University

Research output: Contribution to journal › Review article › peer-review

66 Citations (Scopus)

Abstract

Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.

Original language	English
Pages (from-to)	885-888
Number of pages	4
Journal	ACS nano
Volume	7
Issue number	2
DOIs	https://doi.org/10.1021/nn400560t
Publication status	Published - Feb 26 2013

ASJC Scopus subject areas

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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