Abstract
Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.
| Original language | English |
|---|---|
| Pages (from-to) | 885-888 |
| Number of pages | 4 |
| Journal | ACS Nano |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 26 2013 |
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ASJC Scopus subject areas
- Engineering(all)
- Materials Science(all)
- Physics and Astronomy(all)
Cite this
Tip-enhanced raman imaging : An emergent tool for probing biology at the nanoscale. / Pozzi, Eric A.; Sonntag, Matthew D.; Jiang, Nan; Klingsporn, Jordan M.; Hersam, Mark C; Van Duyne, Richard P.
In: ACS Nano, Vol. 7, No. 2, 26.02.2013, p. 885-888.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tip-enhanced raman imaging
T2 - An emergent tool for probing biology at the nanoscale
AU - Pozzi, Eric A.
AU - Sonntag, Matthew D.
AU - Jiang, Nan
AU - Klingsporn, Jordan M.
AU - Hersam, Mark C
AU - Van Duyne, Richard P.
PY - 2013/2/26
Y1 - 2013/2/26
N2 - Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.
AB - Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.
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U2 - 10.1021/nn400560t
DO - 10.1021/nn400560t
M3 - Article
VL - 7
SP - 885
EP - 888
JO - ACS Nano
JF - ACS Nano
SN - 1936-0851
IS - 2
ER -