Titanium with aligned, elongated pores for orthopedic tissue engineering applications

Erik D. Spoerke, Naomi G D Murray, Huanlong Li, L. Catherine Brinson, David C. Dunand, Samuel I Stupp

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Porous titanium with elongated and aligned pores, mimicking the anisotropic structure of bone, was created by solid-state expansion of argon trapped in elongated pores between titanium wires. Both elastic moduli and yield strengths are larger in the longitudinal direction (E = 51 GPa, σ = 338 MPa) than in the transverse direction (E = 41 GPa, σy = 267 MPa). Finite-element analysis of simplified anisotropic structures provides insight into the local micromechanical behavior of these porous materials, evaluating elastic modulus, resistance to plastic deformation, and localized stress concentrations which may be experienced under biological loading. Preliminary in vitro cell culture studies further demonstrate the influence of the elongated porous microstructure on osteoblast colonization behavior. These studies suggest that as an optimized material, titanium with aligned, elongated pores is promising for applications in orthopedic tissue engineering, as it combines high strength, toughness, and biocompatibility of titanium with the reduced stiffness and open porosity suitable for mechanical integration with bone tissue produced by aligned pores.

Original languageEnglish
Pages (from-to)402-412
Number of pages11
JournalJournal of Biomedical Materials Research - Part A
Volume84
Issue number2
DOIs
Publication statusPublished - 2008

Fingerprint

Orthopedics
Titanium
Tissue engineering
Bone
Elastic moduli
Argon
Osteoblasts
Biocompatibility
Cell culture
Toughness
Yield stress
Porous materials
Stress concentration
Plastic deformation
Porosity
Stiffness
Wire
Tissue
Finite element method
Microstructure

Keywords

  • Anisotropy
  • Bone
  • Finite-element
  • Mechanical properties
  • Orthopedic tissue engineering
  • Osteoblasts
  • Titanium foam

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Titanium with aligned, elongated pores for orthopedic tissue engineering applications. / Spoerke, Erik D.; Murray, Naomi G D; Li, Huanlong; Brinson, L. Catherine; Dunand, David C.; Stupp, Samuel I.

In: Journal of Biomedical Materials Research - Part A, Vol. 84, No. 2, 2008, p. 402-412.

Research output: Contribution to journalArticle

Spoerke, Erik D. ; Murray, Naomi G D ; Li, Huanlong ; Brinson, L. Catherine ; Dunand, David C. ; Stupp, Samuel I. / Titanium with aligned, elongated pores for orthopedic tissue engineering applications. In: Journal of Biomedical Materials Research - Part A. 2008 ; Vol. 84, No. 2. pp. 402-412.
@article{204c219344ac448ca9457a6ea6083e10,
title = "Titanium with aligned, elongated pores for orthopedic tissue engineering applications",
abstract = "Porous titanium with elongated and aligned pores, mimicking the anisotropic structure of bone, was created by solid-state expansion of argon trapped in elongated pores between titanium wires. Both elastic moduli and yield strengths are larger in the longitudinal direction (E = 51 GPa, σ = 338 MPa) than in the transverse direction (E = 41 GPa, σy = 267 MPa). Finite-element analysis of simplified anisotropic structures provides insight into the local micromechanical behavior of these porous materials, evaluating elastic modulus, resistance to plastic deformation, and localized stress concentrations which may be experienced under biological loading. Preliminary in vitro cell culture studies further demonstrate the influence of the elongated porous microstructure on osteoblast colonization behavior. These studies suggest that as an optimized material, titanium with aligned, elongated pores is promising for applications in orthopedic tissue engineering, as it combines high strength, toughness, and biocompatibility of titanium with the reduced stiffness and open porosity suitable for mechanical integration with bone tissue produced by aligned pores.",
keywords = "Anisotropy, Bone, Finite-element, Mechanical properties, Orthopedic tissue engineering, Osteoblasts, Titanium foam",
author = "Spoerke, {Erik D.} and Murray, {Naomi G D} and Huanlong Li and Brinson, {L. Catherine} and Dunand, {David C.} and Stupp, {Samuel I}",
year = "2008",
doi = "10.1002/jbm.a.31317",
language = "English",
volume = "84",
pages = "402--412",
journal = "Journal of Biomedical Materials Research - Part A",
issn = "0021-9304",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Titanium with aligned, elongated pores for orthopedic tissue engineering applications

AU - Spoerke, Erik D.

AU - Murray, Naomi G D

AU - Li, Huanlong

AU - Brinson, L. Catherine

AU - Dunand, David C.

AU - Stupp, Samuel I

PY - 2008

Y1 - 2008

N2 - Porous titanium with elongated and aligned pores, mimicking the anisotropic structure of bone, was created by solid-state expansion of argon trapped in elongated pores between titanium wires. Both elastic moduli and yield strengths are larger in the longitudinal direction (E = 51 GPa, σ = 338 MPa) than in the transverse direction (E = 41 GPa, σy = 267 MPa). Finite-element analysis of simplified anisotropic structures provides insight into the local micromechanical behavior of these porous materials, evaluating elastic modulus, resistance to plastic deformation, and localized stress concentrations which may be experienced under biological loading. Preliminary in vitro cell culture studies further demonstrate the influence of the elongated porous microstructure on osteoblast colonization behavior. These studies suggest that as an optimized material, titanium with aligned, elongated pores is promising for applications in orthopedic tissue engineering, as it combines high strength, toughness, and biocompatibility of titanium with the reduced stiffness and open porosity suitable for mechanical integration with bone tissue produced by aligned pores.

AB - Porous titanium with elongated and aligned pores, mimicking the anisotropic structure of bone, was created by solid-state expansion of argon trapped in elongated pores between titanium wires. Both elastic moduli and yield strengths are larger in the longitudinal direction (E = 51 GPa, σ = 338 MPa) than in the transverse direction (E = 41 GPa, σy = 267 MPa). Finite-element analysis of simplified anisotropic structures provides insight into the local micromechanical behavior of these porous materials, evaluating elastic modulus, resistance to plastic deformation, and localized stress concentrations which may be experienced under biological loading. Preliminary in vitro cell culture studies further demonstrate the influence of the elongated porous microstructure on osteoblast colonization behavior. These studies suggest that as an optimized material, titanium with aligned, elongated pores is promising for applications in orthopedic tissue engineering, as it combines high strength, toughness, and biocompatibility of titanium with the reduced stiffness and open porosity suitable for mechanical integration with bone tissue produced by aligned pores.

KW - Anisotropy

KW - Bone

KW - Finite-element

KW - Mechanical properties

KW - Orthopedic tissue engineering

KW - Osteoblasts

KW - Titanium foam

UR - http://www.scopus.com/inward/record.url?scp=38049068205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049068205&partnerID=8YFLogxK

U2 - 10.1002/jbm.a.31317

DO - 10.1002/jbm.a.31317

M3 - Article

VL - 84

SP - 402

EP - 412

JO - Journal of Biomedical Materials Research - Part A

JF - Journal of Biomedical Materials Research - Part A

SN - 0021-9304

IS - 2

ER -