Towards rapid DMA sequencing: Detecting single-stranded DNA with a solid-state nanopore

Hao Yan, Bingqian Xu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO2. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.

Original languageEnglish
Pages (from-to)310-312
Number of pages3
JournalSmall
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 1 2006

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Keywords

  • DNA
  • Nanopores
  • Sequencing
  • Single-molecule detection

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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