Towards rapid DMA sequencing

Detecting single-stranded DNA with a solid-state nanopore

Hao Yan, Bingqian Xu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO2. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.

Original languageEnglish
Pages (from-to)310-312
Number of pages3
JournalSmall
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 2006

Fingerprint

Nanopores
Single-Stranded DNA
Dynamic mechanical analysis
DNA
Integrated circuits
Membranes
Molecules
Temperature

Keywords

  • DNA
  • Nanopores
  • Sequencing
  • Single-molecule detection

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

Cite this

Towards rapid DMA sequencing : Detecting single-stranded DNA with a solid-state nanopore. / Yan, Hao; Xu, Bingqian.

In: Small, Vol. 2, No. 3, 03.2006, p. 310-312.

Research output: Contribution to journalArticle

@article{971f835abe3046a190e3b5017b41d019,
title = "Towards rapid DMA sequencing: Detecting single-stranded DNA with a solid-state nanopore",
abstract = "Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO2. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.",
keywords = "DNA, Nanopores, Sequencing, Single-molecule detection",
author = "Hao Yan and Bingqian Xu",
year = "2006",
month = "3",
doi = "10.1002/smll.200500464",
language = "English",
volume = "2",
pages = "310--312",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",
number = "3",

}

TY - JOUR

T1 - Towards rapid DMA sequencing

T2 - Detecting single-stranded DNA with a solid-state nanopore

AU - Yan, Hao

AU - Xu, Bingqian

PY - 2006/3

Y1 - 2006/3

N2 - Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO2. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.

AB - Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO2. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.

KW - DNA

KW - Nanopores

KW - Sequencing

KW - Single-molecule detection

UR - http://www.scopus.com/inward/record.url?scp=32344452607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32344452607&partnerID=8YFLogxK

U2 - 10.1002/smll.200500464

DO - 10.1002/smll.200500464

M3 - Article

VL - 2

SP - 310

EP - 312

JO - Small

JF - Small

SN - 1613-6810

IS - 3

ER -