Abstract
There is a great clinical need for tissue engineered blood vessels that could be used to replace or bypass damaged arteries. The success of such grafts will depend strongly on their ability to mimic the cellular and matrix organization found in native arteries, but currently available cell scaffolds such as electrospun fibers or hydrogels lack the ability to simultaneously encapsulate and align cells. Our laboratory has recently developed liquid crystalline solutions of peptide amphiphile nanofibers that form aligned domains at exceedingly low concentrations (99% water by weight, the cells have abundant room for proliferation and remodeling. In contrast to previously reported arterial cell scaffolds, this new material can encapsulate cells and direct cellular organization without the requirement of external stimuli or gel compaction.
| Original language | English |
|---|---|
| Pages (from-to) | 5713-5722 |
| Number of pages | 10 |
| Journal | Biomaterials |
| Volume | 33 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Aug 2012 |
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Keywords
- Arterial tissue engineering
- Biomimetic material
- Circumferential alignment
- Peptide amphiphile
- Self-assembly
- Smooth muscle cell
ASJC Scopus subject areas
- Biomaterials
- Bioengineering
- Ceramics and Composites
- Mechanics of Materials
- Biophysics
Cite this
Tubular hydrogels of circumferentially aligned nanofibers to encapsulate and orient vascular cells. / McClendon, Mark T.; Stupp, Samuel I.
In: Biomaterials, Vol. 33, No. 23, 08.2012, p. 5713-5722.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tubular hydrogels of circumferentially aligned nanofibers to encapsulate and orient vascular cells
AU - McClendon, Mark T.
AU - Stupp, Samuel I
PY - 2012/8
Y1 - 2012/8
N2 - There is a great clinical need for tissue engineered blood vessels that could be used to replace or bypass damaged arteries. The success of such grafts will depend strongly on their ability to mimic the cellular and matrix organization found in native arteries, but currently available cell scaffolds such as electrospun fibers or hydrogels lack the ability to simultaneously encapsulate and align cells. Our laboratory has recently developed liquid crystalline solutions of peptide amphiphile nanofibers that form aligned domains at exceedingly low concentrations (99% water by weight, the cells have abundant room for proliferation and remodeling. In contrast to previously reported arterial cell scaffolds, this new material can encapsulate cells and direct cellular organization without the requirement of external stimuli or gel compaction.
AB - There is a great clinical need for tissue engineered blood vessels that could be used to replace or bypass damaged arteries. The success of such grafts will depend strongly on their ability to mimic the cellular and matrix organization found in native arteries, but currently available cell scaffolds such as electrospun fibers or hydrogels lack the ability to simultaneously encapsulate and align cells. Our laboratory has recently developed liquid crystalline solutions of peptide amphiphile nanofibers that form aligned domains at exceedingly low concentrations (99% water by weight, the cells have abundant room for proliferation and remodeling. In contrast to previously reported arterial cell scaffolds, this new material can encapsulate cells and direct cellular organization without the requirement of external stimuli or gel compaction.
KW - Arterial tissue engineering
KW - Biomimetic material
KW - Circumferential alignment
KW - Peptide amphiphile
KW - Self-assembly
KW - Smooth muscle cell
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UR - http://www.scopus.com/inward/citedby.url?scp=84861347499&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2012.04.040
DO - 10.1016/j.biomaterials.2012.04.040
M3 - Article
VL - 33
SP - 5713
EP - 5722
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 23
ER -