Tubular hydrogels of circumferentially aligned nanofibers to encapsulate and orient vascular cells

Mark T. McClendon, Samuel I Stupp

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

There is a great clinical need for tissue engineered blood vessels that could be used to replace or bypass damaged arteries. The success of such grafts will depend strongly on their ability to mimic the cellular and matrix organization found in native arteries, but currently available cell scaffolds such as electrospun fibers or hydrogels lack the ability to simultaneously encapsulate and align cells. Our laboratory has recently developed liquid crystalline solutions of peptide amphiphile nanofibers that form aligned domains at exceedingly low concentrations (99% water by weight, the cells have abundant room for proliferation and remodeling. In contrast to previously reported arterial cell scaffolds, this new material can encapsulate cells and direct cellular organization without the requirement of external stimuli or gel compaction.

Original languageEnglish
Pages (from-to)5713-5722
Number of pages10
JournalBiomaterials
Volume33
Issue number23
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Nanofibers
Hydrogels
Scaffolds
Blood Vessels
Amphiphiles
Blood vessels
Grafts
Peptides
Compaction
Gels
Tissue
Crystalline materials
Arteries
Water
Fibers
Liquids
Transplants
Weights and Measures

Keywords

  • Arterial tissue engineering
  • Biomimetic material
  • Circumferential alignment
  • Peptide amphiphile
  • Self-assembly
  • Smooth muscle cell

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Tubular hydrogels of circumferentially aligned nanofibers to encapsulate and orient vascular cells. / McClendon, Mark T.; Stupp, Samuel I.

In: Biomaterials, Vol. 33, No. 23, 08.2012, p. 5713-5722.

Research output: Contribution to journalArticle

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