Two-dimensional LNA/DNA arrays

Estimating the helicity of LNA/DNA hybrid duplex

Sherri Rinker, Yan Liu, Hao Yan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero-duplex to be 13.2 ± 0.9 base pairs per turn.

Original languageEnglish
Pages (from-to)2675-2677
Number of pages3
JournalChemical Communications
Issue number25
DOIs
Publication statusPublished - 2006

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Nucleic acids
DNA
Molecules
Atomic force microscopy
Imaging techniques
locked nucleic acid

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Two-dimensional LNA/DNA arrays : Estimating the helicity of LNA/DNA hybrid duplex. / Rinker, Sherri; Liu, Yan; Yan, Hao.

In: Chemical Communications, No. 25, 2006, p. 2675-2677.

Research output: Contribution to journalArticle

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