Abstract
Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006%, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.
| Original language | English |
|---|---|
| Title of host publication | 2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008 |
| Pages | 245-250 |
| Number of pages | 6 |
| Volume | PART A |
| DOIs | |
| Publication status | Published - 2008 |
| Event | 1st ASME Micro/Nanoscale Heat Transfer International Conference, MNHT08 - Tainan, Taiwan, Province of China Duration: Jan 6 2008 → Jan 9 2008 |
Other
| Other | 1st ASME Micro/Nanoscale Heat Transfer International Conference, MNHT08 |
|---|---|
| Country | Taiwan, Province of China |
| City | Tainan |
| Period | 1/6/08 → 1/9/08 |
Fingerprint
Keywords
- Coulter counter
- Microfluidics
- MOSFET
- Resistive pulse sensing
ASJC Scopus subject areas
- Mechanics of Materials
- Materials Science(all)
- Condensed Matter Physics
- Atomic and Molecular Physics, and Optics
Cite this
Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS. / Xu, Dongyan; Kang, Yuejun; Li, Dongqing; Li, Deyu; Sridhar, Manoj; Hmelo, Anthony B.; Feldman, Leonard C.
2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008. Vol. PART A 2008. p. 245-250.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS
AU - Xu, Dongyan
AU - Kang, Yuejun
AU - Li, Dongqing
AU - Li, Deyu
AU - Sridhar, Manoj
AU - Hmelo, Anthony B.
AU - Feldman, Leonard C
PY - 2008
Y1 - 2008
N2 - Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006%, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.
AB - Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006%, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.
KW - Coulter counter
KW - Microfluidics
KW - MOSFET
KW - Resistive pulse sensing
UR - http://www.scopus.com/inward/record.url?scp=49449099347&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49449099347&partnerID=8YFLogxK
U2 - 10.1115/MNHT2008-52249
DO - 10.1115/MNHT2008-52249
M3 - Conference contribution
SN - 0791842924
SN - 9780791842928
VL - PART A
SP - 245
EP - 250
BT - 2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008
ER -