Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS

Dongyan Xu, Yuejun Kang, Dongqing Li, Deyu Li, Manoj Sridhar, Anthony B. Hmelo, Leonard C. Feldman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006%, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.

Original languageEnglish
Title of host publication2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008
Pages245-250
Number of pages6
DOIs
Publication statusPublished - Aug 20 2008
Event1st ASME Micro/Nanoscale Heat Transfer International Conference, MNHT08 - Tainan, Taiwan, Province of China
Duration: Jan 6 2008Jan 9 2008

Publication series

Name2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008
VolumePART A

Other

Other1st ASME Micro/Nanoscale Heat Transfer International Conference, MNHT08
CountryTaiwan, Province of China
CityTainan
Period1/6/081/9/08

Keywords

  • Coulter counter
  • MOSFET
  • Microfluidics
  • Resistive pulse sensing

ASJC Scopus subject areas

  • Mechanics of Materials
  • Materials Science(all)
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Xu, D., Kang, Y., Li, D., Li, D., Sridhar, M., Hmelo, A. B., & Feldman, L. C. (2008). Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS. In 2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008 (pp. 245-250). (2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008; Vol. PART A). https://doi.org/10.1115/MNHT2008-52249