Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS

Dongyan Xu, Yuejun Kang, Dongqing Li, Deyu Li, Manoj Sridhar, Anthony B. Hmelo, Leonard C Feldman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006%, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.

Original languageEnglish
Title of host publication2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008
Pages245-250
Number of pages6
VolumePART A
DOIs
Publication statusPublished - 2008
Event1st ASME Micro/Nanoscale Heat Transfer International Conference, MNHT08 - Tainan, Taiwan, Province of China
Duration: Jan 6 2008Jan 9 2008

Other

Other1st ASME Micro/Nanoscale Heat Transfer International Conference, MNHT08
CountryTaiwan, Province of China
CityTainan
Period1/6/081/9/08

Fingerprint

Fluidic devices
fluidics
Nanofluidics
Modulation
Fluidics
sensors
Sensors
modulation
pulses
Molecules
fluidic circuits
molecules
field effect transistors
Nanopores
Drain current
DNA
microbalances
deoxyribonucleic acid
Networks (circuits)
Monitoring

Keywords

  • Coulter counter
  • Microfluidics
  • MOSFET
  • Resistive pulse sensing

ASJC Scopus subject areas

  • Mechanics of Materials
  • Materials Science(all)
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Xu, D., Kang, Y., Li, D., Li, D., Sridhar, M., Hmelo, A. B., & Feldman, L. C. (2008). Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS. In 2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008 (Vol. PART A, pp. 245-250) https://doi.org/10.1115/MNHT2008-52249

Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS. / Xu, Dongyan; Kang, Yuejun; Li, Dongqing; Li, Deyu; Sridhar, Manoj; Hmelo, Anthony B.; Feldman, Leonard C.

2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008. Vol. PART A 2008. p. 245-250.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Xu, D, Kang, Y, Li, D, Li, D, Sridhar, M, Hmelo, AB & Feldman, LC 2008, Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS. in 2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008. vol. PART A, pp. 245-250, 1st ASME Micro/Nanoscale Heat Transfer International Conference, MNHT08, Tainan, Taiwan, Province of China, 1/6/08. https://doi.org/10.1115/MNHT2008-52249
Xu D, Kang Y, Li D, Li D, Sridhar M, Hmelo AB et al. Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS. In 2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008. Vol. PART A. 2008. p. 245-250 https://doi.org/10.1115/MNHT2008-52249
Xu, Dongyan ; Kang, Yuejun ; Li, Dongqing ; Li, Deyu ; Sridhar, Manoj ; Hmelo, Anthony B. ; Feldman, Leonard C. / Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS. 2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008. Vol. PART A 2008. pp. 245-250
@inproceedings{307c49132aef492cabc9c8cf915f7177,
title = "Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS",
abstract = "Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006{\%}, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.",
keywords = "Coulter counter, Microfluidics, MOSFET, Resistive pulse sensing",
author = "Dongyan Xu and Yuejun Kang and Dongqing Li and Deyu Li and Manoj Sridhar and Hmelo, {Anthony B.} and Feldman, {Leonard C}",
year = "2008",
doi = "10.1115/MNHT2008-52249",
language = "English",
isbn = "0791842924",
volume = "PART A",
pages = "245--250",
booktitle = "2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008",

}

TY - GEN

T1 - Ultrasensitive micro/nanoscale resistive pulse sensors by integrating fluidic devices with MOSFETS

AU - Xu, Dongyan

AU - Kang, Yuejun

AU - Li, Dongqing

AU - Li, Deyu

AU - Sridhar, Manoj

AU - Hmelo, Anthony B.

AU - Feldman, Leonard C

PY - 2008

Y1 - 2008

N2 - Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006%, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.

AB - Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006%, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.

KW - Coulter counter

KW - Microfluidics

KW - MOSFET

KW - Resistive pulse sensing

UR - http://www.scopus.com/inward/record.url?scp=49449099347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49449099347&partnerID=8YFLogxK

U2 - 10.1115/MNHT2008-52249

DO - 10.1115/MNHT2008-52249

M3 - Conference contribution

SN - 0791842924

SN - 9780791842928

VL - PART A

SP - 245

EP - 250

BT - 2008 Proceedings of the ASME Micro/Nanoscale Heat Transfer International Conference, MNHT 2008

ER -