Unprecedented iron-catalyzed ester hydrogenation. Mild, selective, and efficient hydrogenation of trifluoroacetic esters to alcohols catalyzed by an iron pincer complex

Thomas Zell, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

The synthetically important, environmentally benign hydrogenation of esters to alcohols has been accomplished in recent years only with precious-metal-based catalysts. Here we present the first iron-catalyzed hydrogenation of esters to the corresponding alcohols, proceeding selectively and efficiently in the presence of an iron pincer catalyst under remarkably mild conditions. The replacement of precious-metal catalysts by an iron complex was accomplished for the synthetically important, environmentally benign hydrogenation of esters to alcohols under mild conditions. The iron pincer complex (see scheme) selectively and efficiently catalyzes the hydrogenation of trifluoroacetates under remarkably mild conditions (5-25 bar and 40 °C).

Original languageEnglish
Pages (from-to)4685-4689
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number18
DOIs
Publication statusPublished - Apr 25 2014

Keywords

  • esters
  • homogenous catalysis
  • hydrogenation
  • iron complexes
  • pincer ligands

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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