Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols

Jai Anand Garg; Subrata Chakraborty; Yehoshoa Ben-David; David Milstein

doi:10.1039/c6cc01505k

Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols

Jai Anand Garg, Subrata Chakraborty, Yehoshoa Ben-David, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article

57 Citations (Scopus)

Abstract

The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

Original language	English
Pages (from-to)	5285-5288
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	30
DOIs	https://doi.org/10.1039/c6cc01505k
Publication status	Published - Apr 18 2016

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ASJC Scopus subject areas

Chemistry(all)
Catalysis
Ceramics and Composites
Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Materials Chemistry
Metals and Alloys

Cite this

Garg, J. A., Chakraborty, S., Ben-David, Y., & Milstein, D. (2016). Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols. Chemical Communications, 52(30), 5285-5288. https://doi.org/10.1039/c6cc01505k

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Access to Document

10.1039/c6cc01505k