Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols

Jai Anand Garg; Subrata Chakraborty; Yehoshoa Ben-David; David Milstein

doi:10.1039/c6cc01505k

Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols

Jai Anand Garg, Subrata Chakraborty, Yehoshoa Ben-David, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

Original language	English
Pages (from-to)	5285-5288
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	30
DOIs	https://doi.org/10.1039/c6cc01505k
Publication status	Published - Apr 18 2016

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols",

abstract = "The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.",

author = "Garg, {Jai Anand} and Subrata Chakraborty and Yehoshoa Ben-David and David Milstein",

note = "Funding Information: This research was supported by the MINERVA Foundation, by the Israel Science Foundation, and by the Peter Cohn Catalysis Research Fund. D. M. holds the Israel Matz Professorial Chair. J. A. G. and S. C. thank the Swiss Friends of the Weizmann Institute for generous postdoctoral fellowships.",

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AU - Garg, Jai Anand

AU - Chakraborty, Subrata

AU - Ben-David, Yehoshoa

AU - Milstein, David

N1 - Funding Information: This research was supported by the MINERVA Foundation, by the Israel Science Foundation, and by the Peter Cohn Catalysis Research Fund. D. M. holds the Israel Matz Professorial Chair. J. A. G. and S. C. thank the Swiss Friends of the Weizmann Institute for generous postdoctoral fellowships.

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N2 - The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

AB - The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

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