Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols

Jai Anand Garg, Subrata Chakraborty, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journal › Article

54 Citations (Scopus)

Abstract

The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

Original languageEnglish
Pages (from-to)5285-5288
Number of pages4
JournalChemical Communications
Volume52
Issue number30
DOIs
Publication statusPublished - Apr 18 2016

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Trifluoroethanol
Coordination Complexes
Metal complexes
Amides
Hydrogenation
Amines
Alcohols
Iron
Earth (planet)
trifluoroacetamide

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols. / Garg, Jai Anand; Chakraborty, Subrata; Ben-David, Yehoshoa; Milstein, David.

In: Chemical Communications, Vol. 52, No. 30, 18.04.2016, p. 5285-5288.

Research output: Contribution to journal › Article

Garg, JA, Chakraborty, S, Ben-David, Y & Milstein, D 2016, 'Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols', Chemical Communications, vol. 52, no. 30, pp. 5285-5288. https://doi.org/10.1039/c6cc01505k
Garg JA, Chakraborty S, Ben-David Y, Milstein D. Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols. Chemical Communications. 2016 Apr 18;52(30):5285-5288. https://doi.org/10.1039/c6cc01505k
Garg, Jai Anand ; Chakraborty, Subrata ; Ben-David, Yehoshoa ; Milstein, David. / Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols. In: Chemical Communications. 2016 ; Vol. 52, No. 30. pp. 5285-5288.
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