Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols

Jai Anand Garg, Subrata Chakraborty, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

Original languageEnglish
Pages (from-to)5285-5288
Number of pages4
JournalChemical Communications
Volume52
Issue number30
DOIs
Publication statusPublished - Apr 18 2016

Fingerprint

Trifluoroethanol
Coordination Complexes
Metal complexes
Amides
Hydrogenation
Amines
Alcohols
Iron
Earth (planet)
trifluoroacetamide

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols. / Garg, Jai Anand; Chakraborty, Subrata; Ben-David, Yehoshoa; Milstein, David.

In: Chemical Communications, Vol. 52, No. 30, 18.04.2016, p. 5285-5288.

Research output: Contribution to journalArticle

Garg, Jai Anand ; Chakraborty, Subrata ; Ben-David, Yehoshoa ; Milstein, David. / Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols. In: Chemical Communications. 2016 ; Vol. 52, No. 30. pp. 5285-5288.
@article{960439bf42754b67b27857e7bf761949,
title = "Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols",
abstract = "The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.",
author = "Garg, {Jai Anand} and Subrata Chakraborty and Yehoshoa Ben-David and David Milstein",
year = "2016",
month = "4",
day = "18",
doi = "10.1039/c6cc01505k",
language = "English",
volume = "52",
pages = "5285--5288",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "30",

}

TY - JOUR

T1 - Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols

AU - Garg, Jai Anand

AU - Chakraborty, Subrata

AU - Ben-David, Yehoshoa

AU - Milstein, David

PY - 2016/4/18

Y1 - 2016/4/18

N2 - The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

AB - The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

UR - http://www.scopus.com/inward/record.url?scp=84964389819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964389819&partnerID=8YFLogxK

U2 - 10.1039/c6cc01505k

DO - 10.1039/c6cc01505k

M3 - Article

VL - 52

SP - 5285

EP - 5288

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 30

ER -