Using the angle-dependent resonances of molded plasmonic crystals to improve the sensitivities of biosensors

Hanwei Gao, Jiun Chan Yang, Julia Y. Lin, Andreea D. Stuparu, Min Hyung Lee, Milan Mrksich, Teri W. Odom

Research output: Contribution to journalArticle

69 Citations (Scopus)


This paper describes how angle-dependent resonances from molded plasmonic crystals can be used to improve real-time biosensing. First, an inexpensive and massively parallel approach to create single-use, two-dimensional metal nanopyramidal gratings was developed. Second, although constant in bulk dielectric environments, the sensitivities (resonance wavelength shift and resonance width) of plasmonic crystals to adsorbed molecular layers of varying thickness were found to depend on incident excitation angle. Third, protein binding at dilute concentrations of protein was carried out at an angle that optimized the signal to noise of our plasmonic sensing platform. This angle-dependent sensitivity, which is intrinsic to grating-based sensors, is a critical parameter that can assist in maximizing signal to noise.

Original languageEnglish
Pages (from-to)2549-2554
Number of pages6
JournalNano letters
Issue number7
Publication statusPublished - Jul 14 2010



  • Biosensing
  • Molding
  • Plasmonic crystal
  • Protein binding
  • Sensitivity

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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