Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure

Julia H. Ortony, Baofu Qiao, Christina J. Newcomb, Timothy J. Keller, Liam C. Palmer, Elad Deiss-Yehiely, Monica Olvera De La Cruz, Songi Han, Samuel I Stupp

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Water within and surrounding the structure of a biological system adopts context-specific dynamics that mediate virtually all of the events involved in the inner workings of a cell. These events range from protein folding and molecular recognition to the formation of hierarchical structures. Water dynamics are mediated by the chemistry and geometry of interfaces where water and biomolecules meet. Here we investigate experimentally and computationally the translational dynamics of vicinal water molecules within the volume of a supramolecular peptide nanofiber measuring 6.7 nm in diameter. Using Overhauser dynamic nuclear polarization relaxometry, we show that drastic differences exist in water motion within a distance of about one nanometer from the surface, with rapid diffusion in the hydrophobic interior and immobilized water on the nanofiber surface. These results demonstrate that water associated with materials designed at the nanoscale is not simply a solvent, but rather an integral part of their structure and potential functions.

Original languageEnglish
Pages (from-to)8915-8921
Number of pages7
JournalJournal of the American Chemical Society
Volume139
Issue number26
DOIs
Publication statusPublished - Jul 5 2017

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Nanostructures
Water
Nanofibers
Protein folding
Molecular recognition
Protein Folding
Biomolecules
Biological systems
Peptides
Polarization
Molecules
Geometry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Ortony, J. H., Qiao, B., Newcomb, C. J., Keller, T. J., Palmer, L. C., Deiss-Yehiely, E., ... Stupp, S. I. (2017). Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure. Journal of the American Chemical Society, 139(26), 8915-8921. https://doi.org/10.1021/jacs.7b02969

Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure. / Ortony, Julia H.; Qiao, Baofu; Newcomb, Christina J.; Keller, Timothy J.; Palmer, Liam C.; Deiss-Yehiely, Elad; Olvera De La Cruz, Monica; Han, Songi; Stupp, Samuel I.

In: Journal of the American Chemical Society, Vol. 139, No. 26, 05.07.2017, p. 8915-8921.

Research output: Contribution to journalArticle

Ortony, JH, Qiao, B, Newcomb, CJ, Keller, TJ, Palmer, LC, Deiss-Yehiely, E, Olvera De La Cruz, M, Han, S & Stupp, SI 2017, 'Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure', Journal of the American Chemical Society, vol. 139, no. 26, pp. 8915-8921. https://doi.org/10.1021/jacs.7b02969
Ortony JH, Qiao B, Newcomb CJ, Keller TJ, Palmer LC, Deiss-Yehiely E et al. Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure. Journal of the American Chemical Society. 2017 Jul 5;139(26):8915-8921. https://doi.org/10.1021/jacs.7b02969
Ortony, Julia H. ; Qiao, Baofu ; Newcomb, Christina J. ; Keller, Timothy J. ; Palmer, Liam C. ; Deiss-Yehiely, Elad ; Olvera De La Cruz, Monica ; Han, Songi ; Stupp, Samuel I. / Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure. In: Journal of the American Chemical Society. 2017 ; Vol. 139, No. 26. pp. 8915-8921.
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