TY - JOUR
T1 - Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging
AU - Gunanathan, Chidambaram
AU - Pais, Adi
AU - Furman-Haran, Edna
AU - Seger, Dalia
AU - Eyal, Erez
AU - Mukhopadhyay, Sarbani
AU - Ben-David, Yehoshoa
AU - Leitus, Gregory
AU - Cohen, Hagai
AU - Vilan, Ayelet
AU - Degani, Hadassa
AU - Milstein, David
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/9
Y1 - 2007/9
N2 - Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.
AB - Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.
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U2 - 10.1021/bc700230m
DO - 10.1021/bc700230m
M3 - Article
C2 - 17784729
AN - SCOPUS:34648840361
VL - 18
SP - 1361
EP - 1365
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 5
ER -