Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging

Chidambaram Gunanathan, Adi Pais, Edna Furman-Haran, Dalia Seger, Erez Eyal, Sarbani Mukhopadhyay, Yehoshoa Ben-David, Gregory Leitus, Hagai Cohen, Ayelet Vilan, Hadassa Degani, David Milstein

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.

Original languageEnglish
Pages (from-to)1361-1365
Number of pages5
JournalBioconjugate Chemistry
Volume18
Issue number5
DOIs
Publication statusPublished - Sep 1 2007

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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    Gunanathan, C., Pais, A., Furman-Haran, E., Seger, D., Eyal, E., Mukhopadhyay, S., Ben-David, Y., Leitus, G., Cohen, H., Vilan, A., Degani, H., & Milstein, D. (2007). Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging. Bioconjugate Chemistry, 18(5), 1361-1365. https://doi.org/10.1021/bc700230m