Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging

Chidambaram Gunanathan, Adi Pais, Edna Furman-Haran, Dalia Seger, Erez Eyal, Sarbani Mukhopadhyay, Yehoshoa Ben-David, Gregory Leitus, Hagai Cohen, Ayelet Vilan, Hadassa Degani, David Milstein

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.

Original languageEnglish
Pages (from-to)1361-1365
Number of pages5
JournalBioconjugate Chemistry
Volume18
Issue number5
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Magnetic resonance
Estrogen Receptors
Magnetic resonance imaging
Contrast Media
Magnetic Resonance Imaging
Conjugated (USP) Estrogens
Imaging techniques
Water
Cells
Breast Neoplasms
Pyridine
Experiments
Estrogens
pyridine

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging. / Gunanathan, Chidambaram; Pais, Adi; Furman-Haran, Edna; Seger, Dalia; Eyal, Erez; Mukhopadhyay, Sarbani; Ben-David, Yehoshoa; Leitus, Gregory; Cohen, Hagai; Vilan, Ayelet; Degani, Hadassa; Milstein, David.

In: Bioconjugate Chemistry, Vol. 18, No. 5, 09.2007, p. 1361-1365.

Research output: Contribution to journalArticle

Gunanathan, C, Pais, A, Furman-Haran, E, Seger, D, Eyal, E, Mukhopadhyay, S, Ben-David, Y, Leitus, G, Cohen, H, Vilan, A, Degani, H & Milstein, D 2007, 'Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging', Bioconjugate Chemistry, vol. 18, no. 5, pp. 1361-1365. https://doi.org/10.1021/bc700230m
Gunanathan C, Pais A, Furman-Haran E, Seger D, Eyal E, Mukhopadhyay S et al. Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging. Bioconjugate Chemistry. 2007 Sep;18(5):1361-1365. https://doi.org/10.1021/bc700230m
Gunanathan, Chidambaram ; Pais, Adi ; Furman-Haran, Edna ; Seger, Dalia ; Eyal, Erez ; Mukhopadhyay, Sarbani ; Ben-David, Yehoshoa ; Leitus, Gregory ; Cohen, Hagai ; Vilan, Ayelet ; Degani, Hadassa ; Milstein, David. / Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging. In: Bioconjugate Chemistry. 2007 ; Vol. 18, No. 5. pp. 1361-1365.
@article{d26c592dc34649da967341fb41ad3337,
title = "Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging",
abstract = "Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.",
author = "Chidambaram Gunanathan and Adi Pais and Edna Furman-Haran and Dalia Seger and Erez Eyal and Sarbani Mukhopadhyay and Yehoshoa Ben-David and Gregory Leitus and Hagai Cohen and Ayelet Vilan and Hadassa Degani and David Milstein",
year = "2007",
month = "9",
doi = "10.1021/bc700230m",
language = "English",
volume = "18",
pages = "1361--1365",
journal = "Bioconjugate Chemistry",
issn = "1043-1802",
publisher = "American Chemical Society",
number = "5",

}

TY - JOUR

T1 - Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging

AU - Gunanathan, Chidambaram

AU - Pais, Adi

AU - Furman-Haran, Edna

AU - Seger, Dalia

AU - Eyal, Erez

AU - Mukhopadhyay, Sarbani

AU - Ben-David, Yehoshoa

AU - Leitus, Gregory

AU - Cohen, Hagai

AU - Vilan, Ayelet

AU - Degani, Hadassa

AU - Milstein, David

PY - 2007/9

Y1 - 2007/9

N2 - Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.

AB - Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.

UR - http://www.scopus.com/inward/record.url?scp=34648840361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34648840361&partnerID=8YFLogxK

U2 - 10.1021/bc700230m

DO - 10.1021/bc700230m

M3 - Article

VL - 18

SP - 1361

EP - 1365

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

SN - 1043-1802

IS - 5

ER -