Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging

Chidambaram Gunanathan; Adi Pais; Edna Furman-Haran; Dalia Seger; Erez Eyal; Sarbani Mukhopadhyay; Yehoshoa Ben-David; Gregory Leitus; Hagai Cohen; Ayelet Vilan; Hadassa Degani; David Milstein

doi:10.1021/bc700230m

Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging

Chidambaram Gunanathan, Adi Pais, Edna Furman-Haran, Dalia Seger, Erez Eyal, Sarbani Mukhopadhyay, Yehoshoa Ben-David, Gregory Leitus, Hagai Cohen, Ayelet Vilan, Hadassa Degani, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T₁ and T₂ nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.

Original language	English
Pages (from-to)	1361-1365
Number of pages	5
Journal	Bioconjugate Chemistry
Volume	18
Issue number	5
DOIs	https://doi.org/10.1021/bc700230m
Publication status	Published - Sep 2007

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
Pharmacology
Pharmaceutical Science
Organic Chemistry

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10.1021/bc700230m

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Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging. / Gunanathan, Chidambaram; Pais, Adi; Furman-Haran, Edna; Seger, Dalia; Eyal, Erez; Mukhopadhyay, Sarbani; Ben-David, Yehoshoa; Leitus, Gregory; Cohen, Hagai; Vilan, Ayelet; Degani, Hadassa; Milstein, David.

In: Bioconjugate Chemistry, Vol. 18, No. 5, 09.2007, p. 1361-1365.

Research output: Contribution to journal › Article › peer-review

Gunanathan, Chidambaram ; Pais, Adi ; Furman-Haran, Edna ; Seger, Dalia ; Eyal, Erez ; Mukhopadhyay, Sarbani ; Ben-David, Yehoshoa ; Leitus, Gregory ; Cohen, Hagai ; Vilan, Ayelet ; Degani, Hadassa ; Milstein, David. / Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging. In: Bioconjugate Chemistry. 2007 ; Vol. 18, No. 5. pp. 1361-1365.

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AU - Gunanathan, Chidambaram

AU - Pais, Adi

AU - Furman-Haran, Edna

AU - Seger, Dalia

AU - Eyal, Erez

AU - Mukhopadhyay, Sarbani

AU - Ben-David, Yehoshoa

AU - Leitus, Gregory

AU - Cohen, Hagai

AU - Vilan, Ayelet

AU - Degani, Hadassa

AU - Milstein, David

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