Abstract
Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.
| Original language | English |
|---|---|
| Pages (from-to) | 1361-1365 |
| Number of pages | 5 |
| Journal | Bioconjugate Chemistry |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 2007 |
Fingerprint
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Clinical Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
Cite this
Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging. / Gunanathan, Chidambaram; Pais, Adi; Furman-Haran, Edna; Seger, Dalia; Eyal, Erez; Mukhopadhyay, Sarbani; Ben-David, Yehoshoa; Leitus, Gregory; Cohen, Hagai; Vilan, Ayelet; Degani, Hadassa; Milstein, David.
In: Bioconjugate Chemistry, Vol. 18, No. 5, 09.2007, p. 1361-1365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging
AU - Gunanathan, Chidambaram
AU - Pais, Adi
AU - Furman-Haran, Edna
AU - Seger, Dalia
AU - Eyal, Erez
AU - Mukhopadhyay, Sarbani
AU - Ben-David, Yehoshoa
AU - Leitus, Gregory
AU - Cohen, Hagai
AU - Vilan, Ayelet
AU - Degani, Hadassa
AU - Milstein, David
PY - 2007/9
Y1 - 2007/9
N2 - Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.
AB - Novel estrogen-conjugated pyridine-containing Gd(III) and Eu(III) contrast agents (EPTA-Gd/Eu) were designed and effectively synthesized. Convenient to administration and MRI experiments, both EPTA-Gd and EPTA-Eu are soluble in water. The EPTA-Gd selectively binds with a micromolar affinity to the estrogen receptor and induces proliferation of human breast cancer cells. The EPTA-Gd is not lethal and does not cause any adverse effects when administrated intravenously. It enhances T1 and T2 nuclear relaxation rates of water and serves as a selective contrast agent for localizing the estrogen receptor by MRI.
UR - http://www.scopus.com/inward/record.url?scp=34648840361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34648840361&partnerID=8YFLogxK
U2 - 10.1021/bc700230m
DO - 10.1021/bc700230m
M3 - Article
VL - 18
SP - 1361
EP - 1365
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 5
ER -